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abbomax/环磷酸腺苷(cAMP)/100ug/500-9534

价格
面议
货号:500-9534
浏览量:109
品牌:abbomax
服务
全国联保
正品保证
正规发票
签订合同
商品描述
cyclic adenosine monophosphate (cAMP)
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Product Preparation
A chemically linked 3’, 5’-Cyclic Adenosine Monophosphate (cAMP)
Background
Cyclic adenosine monophosphate (cAMP) is an intracellular mediator that plays an important role in a variety ofhormone signaling. It’s been known as an universal cytoplasmic second messenger in drug discovery due to the involvement of G-Protein Coupled Receptors (GPCR) signaling events where the receptorsare activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, etc.
PURIFICATION
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
SPECIFICITY
This antibody recognizes cAMP, not cross react with 5/-AMP, 5’-ADP, 5’-ATP or 3’, 5’-cGMP.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles.
Gene ID
N/A
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5µg/ml
IHC
2-10µg/ml
Flow cytometry
5-10µg/ml
abbomax的14-3-3蛋白是一类小而广泛表达的高度保守的胞质蛋白。14-3-3蛋白与包括Raf,PKC,Bad,Cbl和c-Bcr在内的信号转导,细胞周期调控和细胞凋亡的各种分子结合并影响其活动。14-3-3与靶蛋白之间的相互作用受14-3-3与靶蛋白的磷酸化状态强烈影响。14.3.3β在脑组织中高度表达。这对于细胞转化和有丝分裂信号传导至关重要。