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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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商品描述
JAK2(pY1007/Y1008)
Janus kinase 2
Download Product PDFProduct Preparation
A synthetic peptide surrounding to the epitope-EYYK- withdual phosphorylation sites at Tyr1007 and Tyr1008 of JAK2 from human, mouse and rat origins
Background
The Janus tyrosine kinase family is consists of four members, JAK1, JAK2, JAK3 and Tyk2. Upon the cytokine ligand binding to its the receptors, the dimerization of the receptors occurs followed by phosphorylation of the receptors. The phosphorylation of receptors recruites the tyrosine kinase physically associated to the dimerized receptors, and phosphorylate the kinase, thus activates the signal transducer and activator of thranscription (STAT1, 3, 5) and the other signal proteins.
PURIFICATION The Rabbit IgG is purified by site-modified Epitope Affinity Purification. | SPECIFICITY This antibody recognizes JAK2 with dual phosphorylated sites of Tyr1007/1008. It does not cross-react with non-phosphospecific peptide. |
FORMULATION This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer. | STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles. |
Gene ID
3717
Applications/Suggested Working Dilutions
Western Blot 0.1-1 µg/ml | ELISA 0.01-0.1 µg/ml | Immunoprecipitation 2-5µg/ml | IHC 2-10µg/ml | Flow cytometry 5-10µg/ml |
