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蚂蚁淘在线 / 品牌中心 / Kerafast / Kerafast/Anti-ADAM17 (mouse), Cytoplasmic Domain Antibody/EHS008/100uL

Kerafast/Anti-ADAM17 (mouse), Cytoplasmic Domain Antibody/EHS008/100uL

价格
￥5980.00
货号：EHS008
浏览量：127
品牌：Kerafast
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商品描述

ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheGST-ADAM17-cytoplasmictailandisspecificforthecytoplasmicdomainofmouseADAM17.

TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).

ADAM17(alsoreferredtoasTumorNecrosisFactorConvertase,TACE)isinvolvedintheprocessingoftumornecrosisfactoralpha(TNF-a)atthesurfaceofthecell,andisalsorequiredforsheddingseveralligandsoftheepidermalgrowthfactorreceptorandmanyothermembraneproteins.

FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.

The InvestigatorPartofTheInvestigator"sAnnexeprogram.

Specifications
ProductType: Antibody
Antigen: GST-ADAM17CytoplasmcDomain
MolecularWeight: ~100kDa(matureform),~120kDa(pro-form)
Isotype: IgG
Clonality: Polyclonal
Reactivity: Mouse
Immunogen: GST-cytocorrespondingtothecytoplasmicdomainofmouseADAM17
SpeciesImmunized: Rabbit
Epitope: Cytoplasmicdomain
PurificationMethod: Serum,notpurified
TestedApplications: WB(1:1000)
Storage: -80C
Shipped: Dryice
Research
AntibodySpeciesReactivitySpecificity
ADAM9HumanCytoplasmicDomain
ADAM9MouseCytoplasmicDomain
ADAM12MouseCytoplasmicDomain
ADAM15HumanCytoplasmicDomain
ADAM15MouseCytoplasmicDomain
ADAM15HumanExtracellularDomain
ADAM15MouseDisintegrinDomain
ADAM17MouseCytoplasmicDomain
ADAM17MouseProdomain
ADAM19MouseCytoplasmicDomain
ADAM28MouseCytoplasmicDomain
ADAM28MouseExtracellularDomain
SNX9MouseCytoplasmicDomain
Data

WesternBlotAnalysis

Antibodiesagainst:pro-domainfusedtoGST(α-PRO),cytoplasmicdomainfusedtoGST(α-CYTO).

Adaptedfrom:SchlöndorffJ,etal.JBiochemJ.2000,347,131-138.

Provider
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
Comments

Celllysisbuffermustcontain5mM1,10PhenanthrolinetopreventautodegradationofthematureformofADAM17,whichisnotpreventedbyEDTAortypicalproteaseinhibitorcocktails(Schlöndorffetal.,BiochemJ.2000,347,131-138).

References
  1. Schlöndorff,J.;Becherer,J.D.;Blobel,C.P.Intracellularmaturationandlocalizationofthetumournecrosisfactoralphaconvertase(TACE).BiochemJ.2000,347,131-138.
  2. Zheng,Y.;Schlondorff,J.;Blobel,C.P.Evidenceforregulationofthetumornecrosisfactoralpha-convertase(TACE)byprotein-tyrosinephosphatasePTPH1.J.Biol.Chem.2002,277,42463-42470.
  3. Horiuchi,K.;KimuraT.;MiyamotoT.;TakaishiH.;OkadaY.;Toyama,Y.,Blobel,C.P.Cuttingedge:TNF-alpha-convertingenzyme(TACE/ADAM17)inactivationinmousemyeloidcellspreventslethalityfromendotoxinshock.J.Immunol.2007,179,2686-2689.
  4. LeGall,S.M.,Maretzky,T.,Issuree,P.D.,Niu,X.D.;Reiss,K.,Saftig,P.,Khokha,R.,Lundell,D.,Blobel,C.P.ADAM17isregulatedbyarapidandreversiblemechanismthatcontrolsaccesstoitscatalyticsite.J.Cell.Sci.2010,123,3913-3922.
  5. Maretzky,T.,Evers,A.,Zhou,W.,Swendeman,S.L.,Wong,P.M.,Rafii,S.,Reiss,K.,BlobelC.P.Migrationofgrowthfactor-stimulatedepithelialandendothelialcellsdependsonEGFRtransactivationbyADAM17.Nat.Commun.2011,2,1-25.
  6. McIlwainDR,LangPA,MaretzkyT,HamadaK,OhishiK,ManeySK,BergerT,MurthyA,DuncanG,XuHC,LangKS,HäussingerD,WakehamA,Itie-YoutenA,KhokhaR,OhashiPS,BlobelCP,MakTW.iRhom2regulationofTACEcontrolsTNF-mediatedprotectionagainstListeriaandresponsestoLPS.Science.2012Jan13;335(6065):229-32.

Ifyoupublishresearchwiththisproduct,pleaseletusknowsowecanciteyourpaper.

Kerafast is a Boston-based reagent company whose primary mission is to make unique laboratory-made research tools easily accessible to the global scientific community. Our portfolio includes cell lines, antibodies, small molecules, dyes and more, many of which are not available elsewhere. Since our founding in 2011, researchers from more than 150 institutions worldwide have made their innovative reagents available through our online platform, where the materials can be quickly accessed without needing to go through the traditional Material Transfer Agreement process. We handle all selling and shipping logistics for the providing laboratory, as well as return generous royalty payments from every sale. We therefore help providing labs save time and resources, while generating extra funding for further research. Procuring scientists can more easily discover and access unique reagents that are often unavailable elsewhere, while also funding the work of other researchers.