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蚂蚁淘在线 / 品牌中心 / Immunoway / 免疫法/LY2157299/10mg 50mg 100mg/MC0277

免疫法/LY2157299/10mg 50mg 100mg/MC0277

价格
￥5400.00
货号：MC0277
浏览量：98
品牌：Immunoway
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商品描述

    LY2157299

    • Catalog No.：MC0277
    • Data Sheet
    • MSDS
    • Support
    • Description
    • References ( 0 )
    • Protocol
      • CasNo：
      • 700874-72-2
      • MolecularFormula：
      • C22H19N5O
      • Purity：
      • >98%
      • Target：
      • TGF-β Receptor
      • IC50：
      • IC50: 56 nM (TGF-βR)[1]
      • In Vitro：
      • LY2157299 (Galunisertib) is a selective ATP-mimetic inhibitor of TGF-β receptor (TβR)-I activation LY2157299 (0.1, 1, 10, and 100 μM) displays a slight dose-dependent potentiation of Sorafenib in SK-Sora, HepG2, and Hep3B cell lines but not in JHH6, SK-HEP1, and HuH7 cell lines[2].
      • In Vivo：
      • Human xenografts Calu6 (non-small cell lung cancer) and MX1 (breast cancer) are implanted subcutaneously in nude mice. After oral administration of 75 mg/kg, LY2157299 (Galunisertib) induces a 70% decrease in pSmad for both types of cell lines. The time at which pSmad recovered 80% of baseline is approximately 6 h after administration[3].
      • Fields：
      • LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2.
      • Specificity：
      • Target:TGF-β Receptor. Fields: LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2.
      • Source：
      • Rabbit
      • Dilution：
      • IC50: 56 nM (TGF-βR)[1]
      • Concentration：
      • >98%
      • Storage Stability：
      • 2 years -20°C powder,2 weeks 4°C in DMSO,6 months -80°C in DMSO
      • Other Name：
      • LY-2157299,LY 2157299
      • MolecularWeight(Da)：
      • 369.42
      • References：
      • [1]. Cong L, et al. Targeting the TGF-β receptor with kinase inhibitors for scleroderma therapy. Arch Pharm (Weinheim). 2014 Sep;347(9):609-15.[2]. Serova M, et al. Effects of TGF-beta signalling inh
      • June 19-2018
      • WESTERN IMMUNOBLOTTING PROTOCOL
      • June 19-2018
      • IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
      • June 19-2018
      • IMMUNOFLUORESCENCE PROTOCOL
      • September 08-2020
      • FLOW-CYTOMEYRT-PROTOCOL
      • July 13-2018
      • CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
      • July 13-2018
      • CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
      • July 13-2018
      • CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
      • July 13-2018
      • Antibody-FAQs
      • Products Images
      Immunoway二抗可与酶，生物素或荧光团偶联，可用于多种基于抗体的应用，包括Western Blot，ImmunoHistoChemistry，ImmunoFluorescence，流式细胞术和ELISA。我们为您的每种应用提供来自山羊，兔和驴的高质量二抗。也可以使用血清吸附的二抗，建议将其用于富含免疫球蛋白的样品。