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蚂蚁淘在线 / 品牌中心 / Immunoway / 免疫法/Syk（磷酸化Ser297）兔pAb/20ug 50ug 100ug/YP1519

免疫法/Syk（磷酸化Ser297）兔pAb/20ug 50ug 100ug/YP1519

价格
￥1700.00
货号：YP1519
浏览量：127
品牌：Immunoway
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商品描述

Syk (phospho-Ser297) rabbit pAb

  • Catalog No.：YP1519
  • Applications：WB
  • Reactivity：Human
  • Data Sheet
  • MSDS
  • Support
  • Description
  • References ( 0 )
  • Protocol
    • Gene Name：
    • SYK
    • Protein Name：
    • Syk (Ser297)
    • Human Gene Id：
    • 6850
    • Human Swiss Prot No：
    • P43405
    • Mouse Gene Id：
    • 20963
    • Mouse Swiss Prot No：
    • P48025
    • Rat Gene Id：
    • 25155
    • Rat Swiss Prot No：
    • Q64725
    • Immunogen：
    • Synthesized phosho peptide around human Syk (Ser297)
    • Specificity：
    • This antibody detects endogenous levels ofHuman Syk (phospho-Ser297)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Rabbit
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -20°C/1 year
    • Other Name：
    • Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
    • Observed Band(KD)：
    • 72
    • Background：
    • spleen associated tyrosine kinase(SYK)Homo sapiensThis gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
    • Function：
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.,PTM:Autophosphorylated.,PTM:Phosphorylation on Tyr-323 creates a binding site for c-Cbl, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling.,PTM:Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phas
    • Subcellular Location：
    • nucleus,cytoplasm,cytosol,plasma membrane,B cell receptor complex,extrinsic component of cytoplasmic side of plasma membrane,early phagosome,T cell receptor complex,protein complex,
    • Expression：
    • Eye,Lymph,Ovary,Platelet,Tonsil,
    • June 19-2018
    • WESTERN IMMUNOBLOTTING PROTOCOL
    • June 19-2018
    • IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
    • June 19-2018
    • IMMUNOFLUORESCENCE PROTOCOL
    • June 19-2018
    • FLOW CYTOMEYRT PROTOCOL
    • July 13-2018
    • CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
    • July 13-2018
    • CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
    • July 13-2018
    • CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
    • July 13-2018
    • Antibody-FAQs
    Immunoway二抗可与酶，生物素或荧光团偶联，可用于多种基于抗体的应用，包括Western Blot，ImmunoHistoChemistry，ImmunoFluorescence，流式细胞术和ELISA。我们为您的每种应用提供来自山羊，兔和驴的高质量二抗。也可以使用血清吸附的二抗，建议将其用于富含免疫球蛋白的样品。