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蚂蚁淘在线 / 品牌中心 / Immunoway / Immunoway/PDX-1 Polyclonal Antibody/20ug 50ug 100ug/YT3649

Immunoway/PDX-1 Polyclonal Antibody/20ug 50ug 100ug/YT3649

价格
￥1400.00
货号：YT3649
浏览量：124
品牌：Immunoway
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商品描述

PDX-1 Polyclonal Antibody

  • Catalog No.：YT3649
  • Applications：WB,ELISA
  • Reactivity：Human,Mouse,Rat
  • Data Sheet
  • MSDS
  • Support
  • Description
  • References ( 0 )
  • Protocol
    • Gene Name：
    • PDX1
    • Protein Name：
    • Pancreas/duodenum homeobox protein 1
    • Human Gene Id：
    • 3651
    • Human Swiss Prot No：
    • P52945
    • Mouse Gene Id：
    • 18609
    • Mouse Swiss Prot No：
    • P52946
    • Rat Gene Id：
    • 29535
    • Rat Swiss Prot No：
    • P52947
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human PDX1. AA range:27-76
    • Specificity：
    • PDX-1 Polyclonal Antibody detects endogenous levels of PDX-1 protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Rabbit
    • Dilution：
    • Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -20°C/1 year
    • Other Name：
    • PDX1; IPF1; Pancreas/duodenum homeobox protein 1; PDX-1; Glucose-sensitive factor; GSF; Insulin promoter factor 1; IPF-1; Insulin upstream factor 1; IUF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1
    • MolecularWeight(Da)：
    • 30771
    • Observed Band(KD)：
    • 42
    • Background：
    • pancreatic and duodenal homeobox 1(PDX1)Homo sapiensThe protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008],
    • Function：
    • disease:Defects in PDX1 are a cause of pancreatic agenesis [MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant.,disease:Defects in PDX1 are the cause of maturity onset diabetes noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type II.,disease:Defects in PDX1 are the cause of maturity onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.,domain:The A
    • Subcellular Location：
    • cytosol,nuclear speck,
    • Expression：
    • Pancreatic islet,
    • June 19-2018
    • WESTERN IMMUNOBLOTTING PROTOCOL
    • June 19-2018
    • IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
    • June 19-2018
    • IMMUNOFLUORESCENCE PROTOCOL
    • June 19-2018
    • FLOW CYTOMEYRT PROTOCOL
    • July 13-2018
    • CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
    • July 13-2018
    • CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
    • July 13-2018
    • CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
    • July 13-2018
    • Antibody-FAQs
    Immunoway二抗可与酶，生物素或荧光团偶联，可用于多种基于抗体的应用，包括Western Blot，ImmunoHistoChemistry，ImmunoFluorescence，流式细胞术和ELISA。我们为您的每种应用提供来自山羊，兔和驴的高质量二抗。也可以使用血清吸附的二抗，建议将其用于富含免疫球蛋白的样品。