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蚂蚁淘在线 / 品牌中心 / Immunoway / 免疫法/Stat3（磷酸化-Ser754）兔pAb/20ug 50ug 100ug/YP1513

免疫法/Stat3（磷酸化-Ser754）兔pAb/20ug 50ug 100ug/YP1513

价格
￥1700.00
货号：YP1513
浏览量：82
品牌：Immunoway
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商品描述

Stat3 (phospho-Ser754) rabbit pAb

  • Catalog No.：YP1513
  • Applications：WB
  • Reactivity：Human,Mouse
  • Data Sheet
  • MSDS
  • Support
  • Description
  • References ( 0 )
  • Protocol
    • Gene Name：
    • STAT3 APRF
    • Protein Name：
    • Stat3 (Ser754)
    • Human Gene Id：
    • 6774
    • Human Swiss Prot No：
    • P40763
    • Mouse Gene Id：
    • 20848
    • Mouse Swiss Prot No：
    • P42227
    • Rat Gene Id：
    • 25125
    • Rat Swiss Prot No：
    • P52631
    • Immunogen：
    • Synthesized phosho peptide around human Stat3 (Ser754)
    • Specificity：
    • This antibody detects endogenous levels ofHuman Mouse Stat3 (phospho-Ser754)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Rabbit
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -20°C/1 year
    • Other Name：
    • Signal transducer and activator of transcription 3 (Acute-phase response factor)
    • Observed Band(KD)：
    • 88
    • Background：
    • signal transducer and activator of transcription 3(STAT3) Homo sapiensThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
    • Function：
    • disease:Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.,function:Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.,miscellaneous:Involved in the gp130-mediated signaling pathway.,online information:STAT3 entry,online information:STAT3 mutation db,PTM:Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha an
    • Subcellular Location：
    • nuclear chromatin,nucleus,nucleoplasm,cytoplasm,mitochondrial inner membrane,cytosol,plasma membrane,RNA polymerase II transcription factor complex,
    • Expression：
    • Epithelium,Kidney,Liver,Pancreas,Placenta,
    • June 19-2018
    • WESTERN IMMUNOBLOTTING PROTOCOL
    • June 19-2018
    • IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
    • June 19-2018
    • IMMUNOFLUORESCENCE PROTOCOL
    • June 19-2018
    • FLOW CYTOMEYRT PROTOCOL
    • July 13-2018
    • CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
    • July 13-2018
    • CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
    • July 13-2018
    • CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
    • July 13-2018
    • Antibody-FAQs
    Immunoway二抗可与酶，生物素或荧光团偶联，可用于多种基于抗体的应用，包括Western Blot，ImmunoHistoChemistry，ImmunoFluorescence，流式细胞术和ELISA。我们为您的每种应用提供来自山羊，兔和驴的高质量二抗。也可以使用血清吸附的二抗，建议将其用于富含免疫球蛋白的样品。