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蚂蚁淘在线 / 品牌中心 / Immunoway / 免疫法/Shc（磷酸-Tyr317）兔pAb/20ug 50ug 100ug/YP1489

免疫法/Shc（磷酸-Tyr317）兔pAb/20ug 50ug 100ug/YP1489

价格
￥1700.00
货号：YP1489
浏览量：111
品牌：Immunoway
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商品描述

Shc (phospho-Tyr317) rabbit pAb

  • Catalog No.：YP1489
  • Applications：WB
  • Reactivity：Human,Mouse
  • Data Sheet
  • MSDS
  • Support
  • Description
  • References ( 0 )
  • Protocol
    • Gene Name：
    • SHC1 SHC SHCA
    • Protein Name：
    • Shc (Tyr317)
    • Human Gene Id：
    • 6464
    • Human Swiss Prot No：
    • P29353
    • Mouse Gene Id：
    • 20416
    • Mouse Swiss Prot No：
    • P98083
    • Rat Gene Id：
    • 85385
    • Rat Swiss Prot No：
    • Q5M824
    • Immunogen：
    • Synthesized phosho peptide around human Shc (Tyr317)
    • Specificity：
    • This antibody detects endogenous levels ofHuman Mouse Shc (phospho-Tyr317)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Rabbit
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -20°C/1 year
    • Other Name：
    • SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
    • Observed Band(KD)：
    • 66(p66 isoform), 52(p52 isoform), 46(p46 isoform)
    • Background：
    • SHC adaptor protein 1(SHC1) Homo sapiensThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],
    • Function：
    • domain:In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus
    • Subcellular Location：
    • intracellular,mitochondrial matrix,cytosol,plasma membrane,Shc-EGFR complex,
    • Expression：
    • Brain,Choriocarcinoma,Epithelium,Fibroblast,Mammary gland,Neuroblastoma,Synovium,
    • June 19-2018
    • WESTERN IMMUNOBLOTTING PROTOCOL
    • June 19-2018
    • IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
    • June 19-2018
    • IMMUNOFLUORESCENCE PROTOCOL
    • June 19-2018
    • FLOW CYTOMEYRT PROTOCOL
    • July 13-2018
    • CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
    • July 13-2018
    • CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
    • July 13-2018
    • CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
    • July 13-2018
    • Antibody-FAQs
    Immunoway二抗可与酶，生物素或荧光团偶联，可用于多种基于抗体的应用，包括Western Blot，ImmunoHistoChemistry，ImmunoFluorescence，流式细胞术和ELISA。我们为您的每种应用提供来自山羊，兔和驴的高质量二抗。也可以使用血清吸附的二抗，建议将其用于富含免疫球蛋白的样品。