FPA-124 is a cell-permeable inhibitor of Akt (IC₅₀ = 100 nM), binding to the PH and kinase domains. It inhibits cell proliferation in Colo357, BxPC3, BT20, and PC3 cancer cell lines with IC₅₀ values ranging from 7-55 nM. FPA-124 inhibited tumor growth in mice with negligible toxicity.

References

1) V. Barve, et al. “Synthesis, Molecular Characterization, and Biological Activity of Novel SyntheticDerivatives of Chromen-4-one in Human Cancer Cells” J. Med. Chem., 2006, 49, 3800-3808.2) Biscetti, F., G. Straface, et al. (2009). “Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation.” Cardiovasc Diabetol 8: 49.3) Brito, P. M., R. l. Devillard, et al. (2009). “Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells.” Atherosclerosis 205(1): 126.

Categories	Biochemical Reagents
Filter	Akt, Inhibitor
CAS Number	902779-59-3
Molecular Formula	C11H9Cl2CuN3O2S
Molecular Weight (g/mol)	381.7
Purity	95%
Storage	4 °C or below

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