Sphingosine-1-phosphate (S1P) is a versatile signaling molecule, which is produced by phosphorylation of sphingosine by two distinct sphingosine kinases, SphK1 and SphK2. S1P binds to five G-protein coupled receptors designated S1P_1-5 leading to cell proliferation, motility, survival, and has a role in regulation cell shape and Ca²⁺ homeostasis. VPC23019, an analog of FTY720 (Fingolimod, Gilenya), is a potent anatagonist of the S1P₁ & S1P₃ receptors. VPC23019 will inhibit the migration of various types of cancer cells.

References

1) M. D. Davis, J. J. Clemens, T. L. Macdonald, et al. “Sphingosine 1-phosphate analogs as receptor antagonists.” The Journal of Biological Chemisty, 280 (2005), 9833-9841.2) R.J. Watters, H-G. Wang, et al. “Targeting Sphingosine-1-Phosphate Receptors in Cancer” Anticancer Agents Med Chem., 11 (2011), 810-817.

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Categories	Biochemical Reagents
Filter	Inhibitor, Sphingolipid
CAS Number	449173-19-7
Molecular Formula	C17H29N2O5P
Molecular Weight (g/mol)	372.18
Storage	-20 °C or below

Echelon常用产品报价单产品名货号公司分类商城分类美金价Echelon/Anti-Rat F1-ATP Synthase Alpha Subunit Rabbit Polyclonal Antibody/100 UL/Z-RATPAZ-RATPA功能性抗体400.00Echelon/Biotinylated Anti-PtdIns(3,4)P2 IgG/50 UG/Z-B034Z-B034其它重组蛋白586.00Echelon/Goat anti-human Autotaxin antibody/10 UG/Z-P400Z-P400抗人83.00Echelon/PI4-Kinase beta (PI4Kb), active/5 UG/P32-102GP32-102G激酶226.00Echelon/1-Methylhistamine dihydrochloride/25 MG/B-0032B-0032其他试剂154.00Echelon/Neutral Sphingomyelinase Assay Service/10 SAMPLES/T-1800T-1800脂类663.00Echelon/PI3-K Beta Inhibitor Screening Service/60 Samples/T-1300B-4T-1300B-4脂质代谢研究3407.00Echelon/Cardiolipin Beads/100 UL/P-BCLPP-BCLP微球123.00Echelon/PI3-K Alpha Inhibitor Screening Service/40 SAMPLE/T-1300A-3T-1300A-3多肽2966.00Echelon/5′ PtdIns(3,4,5)P3 Phosphatase Activity Fluorescence Polarization Assay/EA KIT/K-1400K-1400其它检测试剂盒557.00echelon-inc/Sphingosine 1-Phosphate ELISA Kit/1ea/K-1900-1eaK-1900-1eaInhibitors夹心法ELISA1214.00