Echelon/Sphingosine Kinase Inhibitor (SKI-II)/50 mg/B-0024

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¥5300.00
货号:B-0024
浏览量:127
品牌:Echelon
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商品描述

2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2, hPI3K, or hPKCα at concentrations up to 60 μM. SK1-II showed anti-tumor properties, inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins.

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Biochemical Reagents

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Inhibitor, Sphingolipid

CAS Number

312636-16-1

Molecular Formula

C15H11ClN2OS-HCl

Molecular Weight (g/mol)

339.2

Purity

>95%

Storage

4 °C or below

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