Recombinant anti-Tensin 4 Nanobody, Clone # Nb12, COOH-terminal HA tag.Type: VHH single domainSource: E. ColiApplications: ELISA, Immunoprecipitation, Pull downClonality: Monoclonal

Background: Tensin 4 VHH Antibody was produced in an llama with a fragment of Tensin4 encompassing residues 428-714 then cloned for recombinant production in E. Coli. Tensin, aka TNS4 or CTEN, is a component of the cytoskeleton and localizes close to or at focal adhesions, connecting the cytoplasmic tail of integrins with actin filaments. It contains a C-terminal SH2 and PTB (phosphotyrosine binding domain) and binds tyrosine-phosphorylated proteins that assemble into signaling complexes at focal adhesions. Its expression has been reported to be down regulated in prostate cancer, but upregulated in lung and breast cancer.

Recombinant anti-Tensin 4 Nanobody 12 was developed by Gulliver Biomed.

---

Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.

Publications

1) Bertier L, et al. (2018) Nanobodies targeting cortactin proline rich, helical, and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells. Biomed Pharmacother; 102:230-2412) Van Audenhove I, et al. (2016) Nanobodies as versatile tools to understand, diagnose, visualize, and treat cancer. EBioMedicine; 8:40-48

Keywords: Tensin 4, CTEN, TNS4, nanobody, VHH, antibody, single domain

---

‘Nanobody’ and ‘nanobodies’ are registered trademarks of Ablynx N.V.

Categories	Antibodies & Proteins
Filter	Antibody, Nanobody

Echelon常用产品报价单产品名货号公司分类商城分类美金价Echelon/Anti-Rat F1-ATP Synthase Alpha Subunit Rabbit Polyclonal Antibody/100 UL/Z-RATPAZ-RATPA功能性抗体400.00Echelon/Biotinylated Anti-PtdIns(3,4)P2 IgG/50 UG/Z-B034Z-B034其它重组蛋白586.00Echelon/Goat anti-human Autotaxin antibody/10 UG/Z-P400Z-P400抗人83.00Echelon/PI4-Kinase beta (PI4Kb), active/5 UG/P32-102GP32-102G激酶226.00Echelon/1-Methylhistamine dihydrochloride/25 MG/B-0032B-0032其他试剂154.00Echelon/Neutral Sphingomyelinase Assay Service/10 SAMPLES/T-1800T-1800脂类663.00Echelon/PI3-K Beta Inhibitor Screening Service/60 Samples/T-1300B-4T-1300B-4脂质代谢研究3407.00Echelon/Cardiolipin Beads/100 UL/P-BCLPP-BCLP微球123.00Echelon/PI3-K Alpha Inhibitor Screening Service/40 SAMPLE/T-1300A-3T-1300A-3多肽2966.00Echelon/5′ PtdIns(3,4,5)P3 Phosphatase Activity Fluorescence Polarization Assay/EA KIT/K-1400K-1400其它检测试剂盒557.00echelon-inc/Sphingosine 1-Phosphate ELISA Kit/1ea/K-1900-1eaK-1900-1eaInhibitors夹心法ELISA1214.00