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Recombinant Human His10-USP24 Protein, CF Summary
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins.Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration.The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard.In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
E-616
| Formulation | X mg/ml (X μM) is 50 mM HEPES, pH 8.0, 100 mM NaCl, 10% (v/v) Glycerol, 5 mM DTT, 1 mM EDTA |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: USP24
USP24 is a deubiquitinating enzyme (DUB) of the C19 peptidase family. Human USP24 has a predicted molecular weight of 294 kDa and is 98% identical to the mouse orthologue. USP24 reportedly deubiquitinates a wide variety of proteins such as p300, Bax, E2F4, securin, p53 and Mcl-1. In one study, decreased USP24 activity correlated with decreased cell apoptosis and increased cell cycle progression seen in samples from clinical lung cancer patients. Conversely, a compensatory upregulation of USP24 activity resuced myeloma cells from apoptosis when USP9x activity was reduced via RNA-mediated knockdown or chemical inhibition with WP1130. Finally, USP24 is upregulated by DNA damaging agents and plays an important role in maintaining genome stability through its deubiquitination and stabilization of p53. This recombinant enzyme cleaves all poly-Ubiquitin chain linkages in vitro, and contains a c-terminal 10-His tag.
- Peterson L.F. et al. (2015) Blood 125: 3588
- Wang S.A. et al. (2017) Oncogene 36: 2930
- Zhang L. & Gong F. (2016) Mol. Cell Oncol. 3: e1011888
FAQs
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