Boston Biochem/Recombinant Human Ataxin UIM Domains Biotin Protein, CF/UBE-105-250

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¥4900.00
货号:UBE-105-250
浏览量:127
品牌:Boston Biochem
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SummaryProduct DatasheetsBackground

Recombinant Human Ataxin UIM Domains Biotin Protein, CF Summary

The Ubiquitin-interacting Motif (UIM) is an alpha-helical Ubiquitin-binding domain found in many proteins that recognizes and traffics ubiquitinated cargo (1,2). Ataxin-3, a deubiquitinating enzyme that contains three consecutive UIM motifs (amino acids (aa) 224-243, 244-263, 331-348), functions as a mixed lineage, chain editing enzyme that recognizes and binds K48-linked and K63-linked poly-Ubiquitin chains (3-5). The UIM domain of Ataxin-3 (aa 224-348) preferentially interacts with four or more Ubiquitin units of K48-linked or K63-linked poly-Ubiquitin chains or ubiquitinated substrates that contain these linkages (4,6,7).

This protein can be used for the isolation and identification of K48-linked (preferentially) or K63-linked poly-Ubiquitin chains or ubiquitinated substrates that contain these linkages. Detection with avidin-linked reagents allows for a higher efficiency and detection sensitivity than with other antibodies.

Specifications

Source
E. coli
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.
Applications
Enzyme Activity
Species
Human

Product Datasheets

Product Datasheet
COA

Background: Ataxin UIM Domains

Entrez Gene IDs
4287 (Human); 110616 (Mouse); 60331 (Rat)
Alternate Names
Ataxin UIM Domains

Reagents Provided

FAQs

No product specific FAQs exist for this product, however you may

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