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蚂蚁淘在线 / 品牌中心 / Boston Biochem / 波士顿生物化学/重组人His6-USP48蛋白，CF/E-614-050

波士顿生物化学/重组人His6-USP48蛋白，CF/E-614-050

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￥4500.00
货号：E-614-050
浏览量：127
品牌：Boston Biochem
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SummaryProduct DatasheetsCarrier FreeReconstitution CalculatorBackgroundRelated Research Areas

Recombinant Human His6-USP48 Protein, CF Summary

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
Activity
Recombinant Human USP48 is a Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial USP48 concentration of 200-500 nM.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human USP48 protein
Accession #
Q86UV5
Predicted Molecular Mass
120 kDa

Product Datasheets

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins.Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration.The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard.In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

E-614

FormulationX mg/ml (X μM) in 50 mM HEPES pH7.5, 100 mM NaCl, 10% (v/v) Glycerol, 1 mM TCEP
ShippingThe product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: USP48

USP48 is a deubiquitinating enzyme (DUB) of the C19 peptidase family. Human USP48 has a predicted molecular weight of 119 kDa and is 93% and 94% identical to mouse and rat orthologues, respectively. USP48 has been reported to trim K48-linked poly-Ubiquitin chains, an activity that is regulated by Casein Kinase 2 (CK2)-mediated phosphorylation of the DUB. In conjunction with the COP9 signalosome (CSN), nuclear localized USP48 controls the proteasome-dependent turnover of activated NF-kappa B/RelA in the nucleus, thereby contributing to the control of immune responses. USP48 has also been indicated in the regulation of blood pressure and sodium balance via interactions with the dopamine D3 receptor (D3R) and the Na+-H+ exchanger. Finally, USP48 has been reported to stabilize Mdm2 in a manner that is not dependent on it deubiquitinating activity. This recombinant protein contains an N-terminal 6-His tag.

References
  1. Armando I., et al. (2014) FASEB J. 28: 1422
  2. Cetkovska K., et al. (2017) Sci.Rep. 7: 43180
  3. Schweitzer K. & Naumann M.(2015) Biochim Biophys Acta. 1853: 453
Long Name
Ubiquitin Specific Protease 48
Entrez Gene IDs
84196 (Human); 170707 (Mouse); 362636 (Rat)
Alternate Names
Deubiquitinating enzyme 48; DKFZp762M1713; EC 3.1.2.15; EC 3.4.19.12; FLJ11328; FLJ20103; FLJ23054; FLJ23277; MGC132556; MGC14879; RAP1GA1; synUSP; ubiquitin carboxyl-terminal hydrolase 48; ubiquitin specific peptidase 48; ubiquitin specific protease 31; ubiquitin specific protease 48; ubiquitin thioesterase 48; Ubiquitin thiolesterase 48; Ubiquitin-specific-processing protease 48; USP31; USP48

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Boston Biochem2011年，波士顿生物化学被TECHNE Corporation的 R＆D Systems收购，R＆D Systems是细胞生物学试剂的领先供应商，其拥有20多年的经验和独特的产品制造模式，可确保严格的质量控制以及产品中最高的一致性和性能。  凭借R＆D System在销售，分销和物流方面的专业知识，Boston Biochem现在专注于新产品开发。在蛋白质纯化，表征，修饰和分析开发方面的广泛专业知识以及与UPP研究社区的紧密联系使我们能够继续提供最全面的产品范围。我们的收购也使我们有机会共同开发R＆D Systems的互补抗体，ELISA和试剂盒以及Tocris Bioscience的互补抑制剂和底物。波士顿生物化学的所有专用工具将继续在内部进行开发，生产和表征，并致力于提供可负担性和卓越的产品。  2014年，Techne成为Bio-Techne，并与Boston Biochem和R＆D Systems和Tocris的其他核心品牌一起为研究人员提供了广泛的产品和服务。随着我们成为波士顿生物化学品牌-Bio-Techne品牌，您可以期望我们提供与您相同的泛素专业知识和质量。