Human CD134 (OX40) (ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the tumor necrosis factor (TNF) receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation (2).

Isotype: Murine IgG1

Immunogen: Human HUT 102 T cells

Specificity: Antibody BerAct35 recognizes an extracellular epitope of the human CD134 molecule of about 35 kd (1, 3). BerAct35 does not block the interaction between CD134(OX40) and CD252(OX40L).

Functional Application: Antibody BerAct35 inhibited perforin mRNA expression in PHA stimulated PBMC (5).

References:

1. U. Latza, et al, (1994) Eur J Immunol 24: 677-683.

2. E. Stuber, et al, (1995) Immunity 2: 507-521.

3. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 464-465.

4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1157-1160.

5. Ming Li, Yuanchao Zhang (2005) Cell Mol Immunol 2(6):467-271.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。