Human CD44 molecules appear to serve as lymphocyte adhesion molecules with numerous functions in extracellular matrix binding, cell migration, hemopoisis, and lymphocyte homing (3).

Isotype: Murine IgG1k

Immunogen: Human peripheral myeloma cells

Specificity: Antibody BU52 recognizes epitope 1 of the CD44 molecule (2). BU52 is effective for Immunoprecipitation and Immunoblot (6).

References:

1. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 619-627.

2. D.J. Anstee, et al, (1991) Immunology 74: 197-205.

3. B.F. Hynes, et al, (1993) Adv Immunol 54: 271-335.

4. H.X. Liao, et al, (1995) J Immunol 155: 3938-3945.

5. BL Rothman, TM Aune et al,(1991)J Immunol 147(8): 2493-2499

6. Takahashi E, S Hideyuki, et al (2009) JBC 285: 4060-4073.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。