Human CD23 is a low affinity receptor for IgE (Fc epsilon RII) found primarily on mature B cells and also on eosinophils, monocytes, dendritic cells, platelets, and a subset of thymic epithelial cells. CD23 interacts with CD21 (4).

Isotype: Murine IgG1

Immunogen: Human peripheral myeloma cells

Specificity: Antibody BU38 recognizes the CD23 molecule of 45 kd (1, 3).

Functional Application: Antibody BU38 functions as a CD23 agonist when crosslinked with anti-Mouse polyclonal antibody (5,6). Biotinylated BU38 has been used for magnetic depletion of Eosinophils (7).

References:

1. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 67-81.

2. D.L. Hardie, et al, (1993) Eur J Immunol 23: 997-1004.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 530-538.

4. J.Y. Bonnefoy, et al, (1995) Curr Opin Immunol 7: 355-359.

5. M.A. Chan, L.J. Rosenwasser, et al (20103) Clin Immunol 137(3): 330-336.

6. M.A. Chan, L.J. Rosenwasser, et al (2013) Am J Respir Cell Mol Biol doi:10.1165/rcmb.2013-0112OC

7. N Singh, MF Denny, et al. (2016) Dis Model Mech 9(8): 885-97. PMID: 27483354.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。