Human CD56 is an adhesion molecule from the Ig superfamily which is restricted to NK cells in the immune system. It is believed that NK cells form a first line of defense against tumor cells and cells infected with bacteria and viruses. Antibody ERIC-1 recognizes a stem region epitope of the CD56 molecule(4).

Isotype: Murine IgG1 kappa

Immunogen: Human retinoblastoma tumor tissue, membrane fraction (1)

Specificity: Antibody ERIC-1 recognizes the CD56 molecule found on NK cells.

References:

1) S.P. Bourne, et al, (1991) J Neuro-Oncol 10: 111-119.

2) T.L. Whiteside and R.B. Herberman, (1994) Clinical & Diagnostic Laboratory Immunology 1: 125-133.

3) H. Spits, et al, (1995) Blood 85: 2654-2670.

4) R. Gerardy-Schahn, M Eckhardt, (1994) Int J Cancer: Supp 8: 38-42.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。