Expression of human CD25 (the alpha subunit of the IL-2 receptor complex) is dramatically upregulated on activated T cells, B cells, NK cells and macrophages (3). Antibodies to CD25 are being studied for potential use as an immunodirected therapy to selectively attack (kill) CD25 expressing cells (4).

Isotype: Murine IgG2a

Immunogen: Stimulated PBMC

Specificity: Antibody 7G7B6 recognizes epitope B of the IL-2 alpha receptor of about 55 kd (1,6).

Functional Application: Antibody 7G7B6 does not block IL-2 binding to its receptor (1).

References:

1. L.A. Rubin, et al, (1985) Hybridoma 4:91-102.

2. B. Boutin, et al, (1989) Neuropediatrics 20: 202-206.

3. T.A. Waldmann, et al, (1989) Annu Rev Biochem 58: 875-911.

4. T.A. Waldmann, et al, (1995) Blood 86: 4063-4075.

5. U.S. Patent No. 4,707,443.

6. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 403-406.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。