Human CD104 (beta 4 integrin) associates with the alpha 6 integrin chain and binds to laminin and epiligrin and likely has cell-cell adhesion functions. CD104 is involved in signal transduction (4).

Isotype: Murine IgG2a

Immunogen: UM-SCC-1, human squamous cell carcinoma

Specificity: Antibody UMA9 recognizes an extracellular epitope of the CD104 molecule of about 205 kd (1, 3).

Functional Application: Partially blocks laminin binding.

References:

1. K.A. Kimmel & T.E. Carey, (1986) Cancer Res 46: 3614-3623.

2. C VanWaes, et al, (1991) Cancer Res 51: 2395-2402.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1655-1663, 1667-1668.

4. F. Mainiero, et al, (1995) EMBO J 14: 4470-4481.

5. S Tyagi, AR Ahmed, et al. (1996) PNAS 93(25): 14714-14719. PMID: 8962120

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。