Human CD45 is expressed on all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. CD45 plays an essential role in lymphocyte activation (2).

Isotype: Murine IgG2a kappa

Immunogen: Peripheral blood mononuclear cells

Specificity: Antibody C11 recognizes all isoforms of CD45.

References:

1. U. Dianzani, et al, (1992) Eur J Immunol 22: 365-371.

2. I.S. Trowbridge & M.L. Thomas, (1994) Annu Rev Immunol 12: 85-116.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 386-399.

4. D. Leitenberg, et al, (1996) J Exp Med 183: 249-259.

5. M Vigano, de Girolamo, et al. (Feb 2017) J Exp Orthopaedics 4: 8.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。