Human CD27 is a lymphocyte specific member of the tumor necrosis factor (TNF) receptor family and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells. The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily (2, 3). Antibody M-T271 does not block the interaction between CD27 and CD70.

Isotype: Murine IgG1

Immunogen: T cell line (from patient with CLL)

Specificity: Antibody M-T271 recognizes the dimeric CD27 molecule of approximately 110 kd (1, 4) but does not block the interaction between CD70 and CD27. Clone M-T271 has been shown to abrogate IL-4 production(7) or induce apoptosis(6) in MLR . Clone M-T271 is crossreactive with cynomolgus monkey CD27 (8).

References:

1. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 350-352.

2. K. Agematsu, et al, (1994) J Immunol 153: 1421-1429.

3. R.Q. Hintzen, et al, (1994) Immunol Today 15: 307-311.

4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 356-360, 435-437.

5. K. Agematsu, et al, (1995) J Immunol 154: 3627-3635.

6. Wischhusen J, M Weller, et al. (2002) Cancer Res 62: 2592-2599

7. Palmer DR, U Krzych. Eur J Immunol 32(3): 652-661.

8. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。