INFORMATION: Human CD155 (Polio Virus Receptor, PVR, Necl-5) is a 70 kd type I Ig superfamily molecule (1).1 It is involved in formation of intracellular junctions between epithelial cells. Its ligands include CD226(DNAM-1), and CD96(TACTILE). CD155 expression by tumor has been shown to be upregulated by Nitric Oxide(2). A soluble version of CD155 has been shown to exist (4). High CD155 expression has recently been exploited to use engineered poliovirus to treat glioblastoma. (3)

Isotype: Mouse IgG1k

Specificity: Antibody ANC2B2 binds to cell surface CD155 on U-937 cells, and binds to recombinant CD155 in EIA.

Antibodies ANC2B2 and ANC6A3 (Catalog # 350-020) each bind to distict epitopes of CD155 and are suitable as a matched pair for sandwich EIA.

References:

1) Medelsohn CL, Racaniello VR, et al. (1989) Cell 56(5): 855-65.

2) C Fionda, M Cippitelli, et al. (2015) BMC Cancer 15(1):17 PMID 25609078.

3) Gromeier M, Bigner D, et al. (2014) Neuro-Oncology 16(supp3): iii41.

4) Baury B, MG Denis, et al. (2003) Biochem Biophys Res Comm 309: 175-82.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。