Human CD117 (c-kit) is a transmembrane protein with receptor tyrosine kinase capacity and serves as the receptor for steel factor (SLF). CD117 is expressed on almost all hematopoietic progenitor cells and receptor /ligand interaction is crucial for development of hematopoietic stem cells (2, 3).

Isotype: Murine IgG1

Immunogen: Human MO7e tumor cells

Specificity: Antibody 57A5 recognizes extracellular epitope 2 of the human CD117 molecule of about 150 kd.

Functional Application: Antibody 57A5 does not block binding of SCF (4).

References:

1. L.K. Ashman, et al, (1994) J Cellular Physiol 158: 545-554.

2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1856, 1882-1888.

3. J.R. Keller, et al, (1995) Blood 86: 1757-1764.

4. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 816-818.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。