Human CD11c (alpha X integrin) complexes with CD18 (beta 2 integrin) to form the complement receptor type 4 (CR4) heterodimer which binds to fibrinogen and is involved with monocyte/granulocyte adhesion during inflammatory responses (2). CD11c expression is restricted to leukocytes mainly of myeloid lineage with highest expression on macrophages.

Isotype: Murine IgG1

Immunogen: Human rheumatoid synovial fluid cells/monocytes

Specificity: Antibody 3.9 recognizes the human integrin alpha X subunit (CD11c) of about 150 kd (1, 4). It is cross reactive with cynomolgus monkey CD11c (5).

References:

1. N. Hogg, et al, (1986) Eur J Immunol 16: 240-248.

2. S.A. Stacker & T.A. Springer, (1991) J Immunol 146: 648-655.

3. M. Patarroyo, (1994) Immunobiology 191: 474-477.

4. Leukocyte Typing V (1995) (S.F. Schlossman, et al., eds.) Oxford University Press, Oxford,p. 1590-1592.

5. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。