Human CD70 is not present on resting lymphocytes. CD70 is expressed after activation on about 20% of T cells and on about 70% of B cells. CD70 is a ligand for CD27 and it is also a member of the tumor necrosis factor gene family (3).

Isotype: Murine IgG1

Immunogen: Human WM-1 (Waldenström’s macroglobulinemia) cell line

Specificity: Antibody BU69 recognizes the CD70 molecule of approximately 30 kd (3).

Functional Application: Antibody BU69 blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells(5).

References:

1. R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773.

2. M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.

4. K. Agematsu, et al, (1995) J Immunol 154: 3627-3635.

5. S Iwamoto, A Miyazaki, et al, (2005) J Leuk Biol 78: 383-392.

6. Wischhusen J, M Weller, et al. (2002) Cancer Res 62: 2592-2599

7. P.J. Adams, A.L. Harris, et al.(2006) British J Cancer 95:298-306.

8. C Muller, R Kuppers, et al.(2010) Intl Immunol 22(4):289-298.

9. H Yokoi, H Yoshikawa, et al (2003) Lymphology 36: 3674-83. PMID: 12926832

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。