Human CD40 is a member of the tumor necrosis factor (TNF) receptor family and is present on all B cells except plasma cells. CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 Ligand) is essential for isotype switching (3).

Isotype: Murine IgG1

Immunogen: Murine L cells transfectants expressing human CD40

Specificity: Antibody BE-1 recognizes the CD40 molecule of about 44 kd (1, 2).

Functional Application: Binding of cross linked BE-1 will partially activate B cells.

References:

1. C.L. Law, B. Wormann & T.W. LeBien, (1990) Leukemia 4: 732-738.

2. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 90-91.

3. T.A. Foy, et al, (1996) Annu Rev Immunol 14:591-617.

4. M.R. Kuhné , et al, (1997) J Exp Med 186:337-342.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。