Human CD14 is strongly expressed on myelomonocyte lineage cells including monocytes, macrophages, and a subset of granulocytes. CD14 is a high affinity receptor for complexes of lipopolysaccharide and lipopolysaccharide binding protein. A soluble form of CD14 also binds to LPS and LBP (5).

Isotype: Murine IgG2a

Immunogen: Human thymocytes/Sezary T cells

Specificity: Antibody UCHM1 recognizes an extracellular epiotpe of the human CD14 molecule of about 53 kd. UCHM1 will also immunoprecipitate a soluble form of CD14 (1, 2, 3). It is crossreactive with cynomolgus monkey CD14 (6).

References:

1. N. Hogg, et al, (1984) Immunology 53: 753-767.

2. M.O. Labeta, et al, (1993) Eur J Immunol 23: 2144-2151.

3. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989)”Reference Antibody”.

4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 778-788.

5. S.D. Wright, (1995) J Immunol 155: 6-8.

6. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。