Human Lymphotoxin beta receptor (LTbR, TNFSF3) is a member of the TNF receptor superfamily with similarilty to CD120a(TNFR1) and CD120b(TNFR2). It is a expressed mainly on non lymphoid tissues(1) and appears to have an important role in secondary lymphoid organ development(5). Suppression of LTbR signaling can alleviate autoimmunity(2) or exasperate mycobacterial infection(6). Its ligands include Ltab ₂ and LIGHT. In mice, LTbR signaling is important for development and function of HEV(2), Dendritic cells(3), and Mast cells(4).

Molecular Structure: A soluble fusion protein consisting of 10 residual amino acids from murine CD8 alpha leader sequence (KPQAPELRGS), followed by the mature extracellular (192aa) domain of human LTbR (SQPQAVP….PLEPLPP) fused to (233aa) murine IgG2a Fc (EPRGPTI….FSRTPGK). Predicted non glycosylated molecular weight of 48.9 kd.

Transfectant Cell Line: CHO

Functional Application: Recombinant human LTbR-muIg fusion protein binds to recombinant human LIGHT in EIA.

References:

(1)T W Mak, M E Saunders eds. The Immune Response 2006 Elsevier Academic Press p 499.

(2) J L Browning, R.A. Fava, et al. Immunity (2005) 23(5): 539-50.

(3)Y Wang, Y Fu, et al. J Immunol (2005) 175: 6997-7002.

(4)P Stopfer, T Hehlgans, et al. J Immunol (2004) 172: 7459-7465.

(5) Gommermann J, JL Browning, et al, Nat Rev Immunol (2003) 3:642-655.

(6) Spahn TW, T Kucharzik, et al. Infection and Immunity (2005) 73(11): 7077-7088.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。