ISOTYPE: Mouse IgG1k

INFORMATION: The p75 low affinity human Nerve Growth Factor receptor CD271(NGRF, TNFRSF16) is expressed on a variety of tissue types including a subset of splenic and nodal lymphocytes. Presence of this receptor supports uptake of intracellular calcium, but not mobilization (3). CD271 is a stem cell marker for hematopoietic(5,6,7), stromal (8) as well as cancer cells (9,10). CD271 has been reported to inhibit differentiation of mesenchymal cells into various lineages(11).

Antibody ANC271/3D7 binds to recombinant CD271-muIg (cat# 527-020) in EIA, and to endogenous CD271 on cell surface of human Reh cells.

REFERENCES:

1) Brodie C, E W Gelfand (1992) Journal of Immunology. 148(11): 3492-3497.

2) Fantini F, O. Johansson (1992) Journal of Investigative Dermatology. 99(6): 734-742.

3) Jiang H, G Gurogg, et al.(1999) J Biol Chem 274(37): 26209-16.

4) Khwaja F, D Djakiew, et al (2004) Cancer Res 64(17): 6207-13.

5) Flores-Torales E, Cuneo-Pareto S, et al. (2010) Folia Histochem Cytobiol. 48(4):682-6.

6) Kuçi S, Bader P, et al. (2010) Haematologica. 95(4):651-9.

7) Hermida-Gómez T, Blanco FJ, et al. (2011) Tissue Eng Part A. 17(7-8):1169-79.

8) Jones E, McGonagle D, et al. (2010) Arthritis Rheum. 62(7):1944-54.

9) Boiko AD, Weissman IL. Et al. (2010) Nature 466(7302):133-7.

10) Civenni G, Sommer L, et al. (2011) Cancer Res. 71(8):3098-109.

11) Mikami Y, Honda MJ, et al. (2011) Stem Cells Dev. 20(5):901-13.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。