Human CD11a (alpha L integrin) complexes with CD18 (beta 2 integrin) to form the LFA-1 heterodimer adhesion molecule which binds to three ICAM’s 1, 2, and 3, also designated CD54, CD102, and CD50 respectively. LFA-1 is expressed on lymphocytes, monocytes and neutrophils and plays a role in cell-cell adhesion (6).

Isotype: Murine IgG2a

Immunogen: Human monocytes

Specificity: Antibody 38 recognizes the I domain of the human integrin alpha L subunit (CD11a) of about 180 kd (1, 3, 7).

Functional Application: Antibody 38 blocks binding of ICAM-1 and ICAM-3 to LFA-1 at 5-10 ug/ml (7, 9).

References:

1. I. Dransfield & N. Hogg, (1989) EMBO J 12: 3759-3765.

2. I. Dransfield, et al, (1992) J Cell Biol 116: 1527-1535.

3. R.C. Landis, et al, (1994) J Cell Biol 126: 529-537.

4. A.M. Randi & N. Hogg, (1994) JBC 269:12395-12398.

5. P. Stanley, et al, (1994) EMBO J 13:1790-1798

6. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1581-1592.

7. C.L. Holness, et al, (1995) J Biol Chem 270: 877-884.

8. M. Galdiero, et al. Microbiology 147 (2001), 2697-2704

9. T Mizuno, K Mori, et al (1996) J Biol Chem 272(2): 1156-63. PMID: 8995416

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。