Human CD31 is an adhesion molecule expressed on platelets, endothelial cells, leukocytes and their bone marrow precursors. CD31 plays a role in homophilic adhesion and heterophilic transendothelial migration (3).

Isotype: Murine IgG1

Immunogen: Stimulated human leukocytes

Specificity: Antibody 158-2B3 reacts with domain 1 of CD31 (1).

Functional Application: Antibody 158-2B3 blocks homophilic interaction and heterophilic transendothelial migration(1). It has been used for FACS analysis of circulating Endothelial Microparticles (4).

References:

1. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 362-372.

2. P.J. Newman, (1997) J Clin Invest 99: 3-10.

3. K.L. Yong, et al, (1998) Blood 91: 1196-1205.

4. AF Tramontano, L Ragolia, et al. (2010) Mediators of Inflammation 2010: 250476 doi:10.1155/2010/250476.

5. I Soaita, W Yin, D A Rubenstein (Jan 2017) Platelets http://dx.doi.org/10.1080/09537104.2016.1260703

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。