Human CD10 is a well known marker for common acute lymphoblastic leukemia antigen (CALLA) (4). CD10 is expressed on normal early B cells in bone marrow and is also on fetal thymocytes. CD10 expression is lost as the T and B lineage cells mature and only appears again on activated germinal center B cells. CD10 is present on neutrophils. CD10 is a neutral endopeptidase and hydrolyzes peptide bonds on the amino side of hydrophobic amino acids.

Isotype: Murine IgG1kappa

Immunogen: Membrane preparation of human B-lineage leukemia cells

Specificity: Antibody SN5c recognizes an extracellular epitope of the the human 100 kd membrane-associated peptidase CD10 (1, 2, 3).

References:

1. H. Matsuzaki, et al, (1987) Cancer Research 47: 2160-2166.

2. W.C. Biddle, et al, (1989) Leukemia Research 13: 699-707.

3. H. Hara, et al, (1988) Cancer Research 48: 4673-4680.

4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 505-507.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。