Human CD48 (SLAMF2) is a GPI anchored cell surface gylcoprotein found on all lymphocytes and monocytes. CD48 is a ligand for CD2 as well as CD229 and CD244(2B4, SLAMF4), and may be involved in enhancing the activating signal to B cells.

Isotype: Murine IgG2a

Immunogen: Human PBLs

Specificity: Clone 5-4.8 recognizes epitope 4 of the CD48 molecule of about 47 kd (4). This mAb blocks binding of biotinylated recombinant CD244(2B4,SLAMF4)-muIg (Cat# 544-030) to CD48 in FACS.

References:

1. H.A. Vaughan, et al, (1983) Transplantation 36: 446-450.

2. H.A. Vaughan, et al, (1991) Immunogenetics 33: 113-117.

3. E.N. Klyushnenkova, et al, (1996) Cellular Immunol 174: 90-98.

4. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 509-512.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。