CD127 (IL-7Ra) is the specific receptor component for the cytokine Interleukin -7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors, and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132(IL-2Rg) to form a high affinity IL-7 receptor (1). CD127 engagement is necessary for T cell development in humans (2).

Isotype: Murine IgG1 kappa

Immunogen: Recombinant human CD127

Specificity: Antibody ANC8F2 recognizes an extracellular epitope of human recombinant and native CD127 in FACS and Enzyme Immunoassay.

References:

1) Noguchi, M. et al., 1993, Science 262:1877.

2) Pribyl, J.A. and T.W. LeBien, 1996, Proc. Natl. Acad. Sci. 93:10348.

3) Goodwin RG, Friend D, Ziegler SF, et al. Cell. 1990;60:941.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。