Glucocorticoid induced Tumor Necrosis Factor receptor family related gene (GITR, AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18. GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break T cell suppression (2). GITR has been implicated as a regulatory mechanism in anti-parasitic immune resposes (4), and is involved with Macrophages activation in atherosclerotic plaque formation (3).

Clone ANC7D6-1E7 binds to human GITR in EIA and on stimulated cell surface in FACS. Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.

Isotype: Murine IgM kappa

Immunogen: Recombinant human GITR, PHA stimulated human PBL

Specificity: Antibody ANC7D6-1E7 binds to human GITR in EIA and on cell surface in FACS. Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.

References:

1) Gurney AL, et al. (1999) Curr Biol 9(4): 215-218.

2) Ji HB, et al. (2004 ) J Immunol 172(10): 5823-5827.

3) Kim WJ, WH Lee, et al. (2006) Immunology 119(3): 44-9.

4) Furze RC, Selkirk ME, et al. (2006) Microbes Infect 8 (12-13): 2803-10.

5) Kohm AP, SD Miller, et al. (2004) J Immunol 172: 4686-4690. .

6) McHugh, R.S. et al. (2002) Immunity 16:311.

7) Shin, H.H. et al. (2002) FEBS Lett. 514:275.

8). Shimizu, J. et al. (2002) Nature Immunol. 3:135.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。