DescriptionSequence(One-Letter Code)

Product Name	OVA (257 - 264)SIINFEKL
Size	5 mg
Catalog #	AS-60193-5
US$	$208
Purity	% Peak Area By HPLC ≥ 95%
This is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb.
Detailed Information	Datasheet Material Safety Data Sheets (MSDS)
Storage	-20°C
References	Werlen, G. et al. Nature 406, 422 (2000); Maecker, H. et al. J. Immunol. 161, 6532 (1998).
Molecular Weight	963.2
SIINFEKL
Sequence(Three-Letter Code)	H - Ser - Ile - Ile - Asn - Phe - Glu - Lys - Leu - OH
Product Citations	Krueger PD, et al. (2016) Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8+ T cells. J. Leukoc. Biol.. 101:329-338 doi: 10.1189/jlb.3A0516-225RLitterman, A.J. et al. (2013). Profound impairment of adaptive immune responses by alkylating chemotherapy J Immunol 190 6259doi: 10.4049/​jimmunol.1203539.Sawada, Y. et al. (2014). Programmed death-1 blockade enhances the antitumor effects of peptide vaccine-induced peptide-specific cytotoxic T lymphocytes. Intl J Oncol doi: 10.3892/ijo.2014.2737.Ofuji, K. et al. (2014). A peptide antigen derived from EGFR T790M is immunogenic in non‑small cell lung cancer Intl J Oncol doi: 10.3892/ijo.2014.2787.Fun Tang, M.et al. (2014). The DNA damage response induces antigen presenting cell-like functions in fibroblasts Eur J Immunol 44, 923, doi: 10.1002/eji.201343781.Silva, O. et al. (2015). Discs large homolog 1 splice variants regulate p38 –dependent and –independent effector functions in CD8+ T Cells PLoS One doi: 10.1371/journal.pone.0133353.Mamonkin, M. et al.(2014). Transcription factor ELF4 promotes development and function of memory CD8+ T cells in Listeria monocytogenes infection Eur J Immunol 44 doi: 10.1002/eji.201343775.Hayes, C. S. et al. (2013). Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment cancer Immunol res doi: 10.1158/2326-6066.CIR-13-0120-T.Trepanier, P. et al. (2014). Intravenous immunoglobulin modulates the expansion and cytotoxicity of CD8+ T cells Brit Soc Immunol doi: 10.1111/imm.12189.Baroja-Mazo, A. et al. (2013). P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells PLoS One doi: 10.1371/journal.pone.0070577.Guo, C. et al. (2012). In situ vaccination with CD204 gene-silenced dendritic cell, not unmodified dendritic cell, enhances radiation therapy of prostate cancermol cancer ther dot: 10.1158/1535-7163.MCT-12-0164.Nobuoka, D. (2013). Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy Pubmed doi: 10.1007/s00262-012-1366-6.Larghi, P. (2012). The p50 subunit of NF-κB orchestrates dendritic cell lifespan and activation of adaptive immunity PLoS One doi: 10.1371/journal.pone.0045279.Faisal, S. et al. (2011). Immunostimulatory and antigen delivery properties of liposomes made up of total polar lipids from non-pathogenic bacteria leads to efficient induction of both innate and adaptive immune responses. Vaccine 10.1016/j.vaccine.2011.01.110.Durgan, K. et al. (2010). Targeting NKT cells and PD-L1 pathway results in augmented anti-tumor responses in a melanoma model. Cancer Immunol Immunotherapy 10.1007/s00262-010-0963-5.Fletcher, A. et al. (2010). Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions JEM 207, 689.Kelly, R. et al. (2010). Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation. Blood 115, 1088.Ordaz, M. et al. (2010). DC-expressed MHC class I single-chain trimer-based vaccines prime cytotoxic T lymphocytes against exogenous but not endogenous antigens. Cell Immunol 262, 141.Sun X. et al. (2010). Enhanced in vivo gene expression mediated by listeriolysin o incorporated anionic LPDII: Its utility in cytotoxic T lymphocyte-inducing DNA vaccine. J Control Release 10.1016/j.jconrel.2010.06.017.Nakayama, M. et al. (2009). Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood 113, 3821.Peng, Y. et al. (2009). Ly6Clow monocytes differentiate into dendritic cells and cross-tolerize T cells through PDL-1. Blood 182, 2777.Qu, C. et al. (2009). MHC class I/peptide transfer between dendritic cells overcome poor cross-presentation by monocyte-derived APCs that engulf dying cells. J Immunol 182, 3650.Kelly, RM. et al. (2008). Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation. Blood 111, 5734.Towne, CF. et al. (2008). Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. J Immunol 180, 1704.Kislin, KL. et al. (2007). Chaperone-rich cell lysate embedded with BCR-ABL peptide demonstrates enhanced anti-tumor activity against a murine BCR-ABL positive leukemia. FASEB J 21, 2173.Sato, N. et al. (2007). The IL-15/IL-15R on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells. PNAS 104, 588.Cante-Barnett, K. et al. (2006). Thymocyte negative selection is mediated by protein kinase C-and Ca2+ -dependent transcriptional induction of Bim. J Immunol 176, 2299.Ren, Y. et al. (2006). OVA-specific CD8+T cells do not express granzyme B during anterior chamber associated immune deviation. Graefe"s ARch Clin Exp Ophthalmol 244, 1315.Galibert, L. et al. (2005). Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. J Biol Chem 280, 21955.Komlosh, A. et al. (2001). A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides. J Biol Chem 276, 30050.Ben-Shahar, S. et al. (1999). 26 S proteasome-mediated production of an authentic major histocompatibility classI-restricted epitope from an intact protein substrate. J Biol Chem 274, 21963.Ben-Shahar, S. et al. (1997). Production of a specific major histocompatibility complex class I-restricted epitope by ubiquitin-dependent degradation of modified ovalbumin in lymphocyte lysate. J Biol Chem 272, 21060.Lyszkiewicz, M. et al. (2011). SIGN-R1+MHC II+ cells of the splenic marginal zone—a novel type of resident dendritic cells. J Leukocyte Biol89 607. doi: 10.1189/jlb.0610368.

Anaspec在过去的二十年中，荧光检测生理学和神经学信号受到了极大的关注。使用分子荧光或发光来感测生理和神经信号具有若干优点。其中包括高灵敏度（低至单个分子），开-关切换性，活细胞通信的可行性，具有亚微米可视化的亚纳米空间分辨率和亚毫秒级时间分辨率。光诱导电子转移（PET）和电子能量转移（EET）主要用于将离散的和化学计量的识别事件转换为荧光信号。基于PET效应，开发了许多荧光生理指示剂（如下所述）。AnaSpec提供高质量和具有竞争力的价格的多种生理和神经指标（例如Fura-2，Indo-1和Rhod-2），用于各种生物学应用。AnaSpec努力提供可在任何地方使用的最高纯度的指标。通过HPLC分析，我们的UltraPure级AM荧光指示剂酯的纯度通常至少为95％，尽管纯度通常超过98％。此外，我们还为您提供许多Ca2 +指示剂的AM酯的定制包装服务，以最小的费用为您提供便利，并降低了存储期间变质的风险。