DescriptionSequence(One-Letter Code)

Product Name	Endothelin 1, human, porcineCSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1 - 15 and 3 - 11)
Size	0.5 mg
Catalog #	AS-22860
US$	$300
Purity	% Peak Area By HPLC ≥ 95%
ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.
Detailed Information	Datasheet Material Safety Data Sheets (MSDS)
Storage	-20°C
References	Ref: Yanagisawa, M. et al. Nature. 332, 411 (1988).
Molecular Weight	2492
CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1-15 and 3-11)
Sequence(Three-Letter Code)	H - Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - OH (Disulfide bridge: 1 - 15 and 3 - 11)
Product Citations	Ansar, S. et al. (2009). Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. J Neurosurg 111, 5.Wang, Y. et al. Brain Res. 1167, 118 (2007).Cervar-Zivkovic, M. et al. Reprod. Sci. 14, 430 (2007).Beg, SAS. et al. J. Cer. Blood Flow Metab. 26, 846 (2006).Ansar, S. et al. J. Neurosurgery 106, DOI: 10.3171/jns.2007.106.5.881 (2006).

Anaspec在过去的二十年中，荧光检测生理学和神经学信号受到了极大的关注。使用分子荧光或发光来感测生理和神经信号具有若干优点。其中包括高灵敏度（低至单个分子），开-关切换性，活细胞通信的可行性，具有亚微米可视化的亚纳米空间分辨率和亚毫秒级时间分辨率。光诱导电子转移（PET）和电子能量转移（EET）主要用于将离散的和化学计量的识别事件转换为荧光信号。基于PET效应，开发了许多荧光生理指示剂（如下所述）。AnaSpec提供高质量和具有竞争力的价格的多种生理和神经指标（例如Fura-2，Indo-1和Rhod-2），用于各种生物学应用。AnaSpec努力提供可在任何地方使用的最高纯度的指标。通过HPLC分析，我们的UltraPure级AM荧光指示剂酯的纯度通常至少为95％，尽管纯度通常超过98％。此外，我们还为您提供许多Ca2 +指示剂的AM酯的定制包装服务，以最小的费用为您提供便利，并降低了存储期间变质的风险。