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蚂蚁淘在线 / 品牌中心 / Anaspec / Anaspec/SensoLyte ® Plus 520 MMP - 1 Assay Kit *Fluorimetric and Enhanced Selectivity*/1 kit/AS-72012

Anaspec/SensoLyte ® Plus 520 MMP - 1 Assay Kit *Fluorimetric and Enhanced Selectivity*/1 kit/AS-72012

价格
￥12020.00
货号：AS-72012
浏览量：127
品牌：Anaspec
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Product NameSensoLyte ® Plus 520 MMP - 1 Assay Kit*Fluorimetric and Enhanced Selectivity*
Size1 kit
Catalog #AS-72012
US$$601

The SensoLyte® Plus 520 MMP-1 Assay Kit is designed for specifically detecting MMP-1 activity in biological samples which may contain multiple MMPs, such as culture medium, serum, plasma, synovial fluid, and tissue homogenate. A specific anti-MMP-1 monoclonal antibody is used in combination with an MMP fluorogenic substrate, 5-FAM/QXL®520 FRET peptide. The fluorescence signal is monitored at Ex/Em=490 nm/520 nm upon MMP-1-induced cleavage of the FRET substrate. Ample materials are provided to perform 96 assays in a 96-well format.

Detailed InformationDatasheet
Material Safety Data Sheets (MSDS)
Poster
ReferencesJian J, Pelle E, Yang Q, Pernodet N, Maes D, Huang X. Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-? and ERK activation. Exp Dermatol. 2011 Mar; 20(3):249-54. PMID:20701626
Product CitationsCarrizzo, A. et al. (2015). Pentraxin 3 induces vascular endothelial dysfunction through a P-selectin/Matrix Metalloproteinase-1 pathway. Circulation 131, 1495. doi: 10.1161/CIRCULATIONAHA.114.014822.Atay, S. et al. (2014). Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion. PNAS 111, 711. doi: 10.1073/pnas.1310501111.Halvorsen, B. et al. (2014). Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells. Cardiovasc Res 102, 148. doi: 10.1093/cvr/cvu036.Mogami, H. et al. (2014). Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J Biol Chem 289, 13295. doi: 10.1074/jbc.M114.550541.Ozeki, N. et al. (2014). IL-1β-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells. Exp Cell Res 323, 165.Mogami, H. et al. (2013) Fetal fibronectin signaling induces Matrix Metalloproteases and Cyclooxygenase-2(COX-2) in amnion cells and preterm birth in mice JBC 2883,1953 doi:10.1074/jbc.M112.424366Bogatkevich, GS. et al. (2012). The PPARγ agonist Rosiglitazone is antifibrotic for scleroderma lung fibroblasts: mechanisms of action and differential racial effects. Pulmonary Med doi:10.1155/2012/545172Leong, D. et al. (2011). Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J 25, 182.Park, C. et al. (2011). Epidermal growth factor-induced matrix metalloproteinase-1 expression is negatively regulated by p38 MAPK in human skin fibroblasts. J Dermatol Sc 64, 134.Handy, J. et al. (2010). Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3). J Cell Biochem 110, 1195.Cowan, RW. et al. (2009). Collagenase expression and activity in the stromal cells from giant cell tumour of bone. Bone 44, 865.Jian, J. et al. (2011). Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-α and ERK activation. Exp Dermatol 20, 249.Moor, A. et al. (2009). Proteolytic activity in wound fluids and tissues derived from chronic venous leg ulcers. Wound Repair Regen 17, 832.Shi, Z-D. et al. (2009). Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1. Am J Physiol Heart Circ Physiol 10.1152/ajpheart.00369.2009.Qazi, H. et al. (2011). Fluid shear stress regulates the invasive potential of glioma cells via modulation of migatory activity and matrix metalloproteinase expression. PLoS One 6, e20348.
Anaspec在过去的二十年中，荧光检测生理学和神经学信号受到了极大的关注。使用分子荧光或发光来感测生理和神经信号具有若干优点。其中包括高灵敏度（低至单个分子），开-关切换性，活细胞通信的可行性，具有亚微米可视化的亚纳米空间分辨率和亚毫秒级时间分辨率。光诱导电子转移（PET）和电子能量转移（EET）主要用于将离散的和化学计量的识别事件转换为荧光信号。基于PET效应，开发了许多荧光生理指示剂（如下所述）。AnaSpec提供高质量和具有竞争力的价格的多种生理和神经指标（例如Fura-2，Indo-1和Rhod-2），用于各种生物学应用。AnaSpec努力提供可在任何地方使用的最高纯度的指标。通过HPLC分析，我们的UltraPure级AM荧光指示剂酯的纯度通常至少为95％，尽管纯度通常超过98％。此外，我们还为您提供许多Ca2 +指示剂的AM酯的定制包装服务，以最小的费用为您提供便利，并降低了存储期间变质的风险。