Anaspec/Ghrelin,大鼠,小鼠/5 mg/AS-24160

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¥19940.00
货号:AS-24160
浏览量:127
品牌:Anaspec
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商品描述
DescriptionSequence(One-Letter Code)
Product NameGhrelin, rat, mouseGS - S(n - octanoyl) - FLSPEHQKAQQRKESKKPPAKLQPR
Size5 mg
Catalog #AS-24160
US$$997
Purity% Peak Area By HPLC ≥ 95%

Rat/mouse Ghrelin differs from human Ghrelin on the 11th and 12th position - RV (Arg-Val) in rat/mouse and KA (Lys-Ala) in human.Ghrelin is an appetite stimulating peptide hormone secreted by stomach P/D1-type cells in humans and circulates in the bloodstream during fasting conditions.  Enzymatically n-octanoylated Serine3 of this 28-amino acid Ghrelin is the endogenous ligand specific for growth hormone secretagogue receptor 1a (GHSR1a). The GHSR1a receptor appears to be dedicated to Ghrelin and is widely expressed in different tissues. 

Detailed InformationDatasheet
Material Safety Data Sheets (MSDS)
Storage-20°C
ReferencesKojima, M. et al. Nature 402, 656 (1999), doi:10.1038/45230Yang J., et. al. Cell 132, 387 (2008).doi: 10.1016/j.cell.2008.01.017 Kojima, M. et. al. Physiol Rev 85, 495 (2005), doi: 10.1152/physrev.00012.2004 Perello, M. & Dickson, SL. J Neuroendocrinol 27, 424 (2015), doi: 10.1111/jne.12236
Molecular Weight3314.8
GS-S(n-octanoyl)-FLSPEHQKAQQRKESKKPPAKLQPR
Sequence(Three-Letter Code)H - Gly - Ser - [Ser(n - octanoyl)] - Phe - Leu - Ser - Pro - Glu - His - Gln - Lys - Ala - Gln - Gln - Arg - Lys - Glu - Ser - Lys - Lys - Pro - Pro - Ala - Lys - Leu - Gln - Pro - Arg - OH
Product CitationsOzfiliz, N. et al. (2011). Effects of different feeding programs and ghrelin injection on plasma ghrelin concentrations and distribution of the ghrelin positive cells in the abomasum of Awassi male lambs. Revue Med Vet 162, 65.Guneli, E. et a. (2010). Effects of repeated administered ghre3lin on chronic constriction injury of the sciatic nerve in rats. Neurosci Lett 479, 226.Granado, M. et al. (2009). Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats. Mol Cell Endocrinol 309, 67.Xu, J. et al. (2009). Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 453, 58.Waseem, T. et al. (2008). Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 143, 334. Yang, J. et al. (2008). Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132, 387.Barazzoni, R. et al. (2007). Ghrelin enhances in vivo skeletal muscle but not liver AKT signaling in rats. Obesity 15, 2614.Liu, Y. et al. (2006). Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin J Physiol 49, 244.Barazzoni, R. et al. (2004). Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. AJP-Endo Metab 288, E228.
Anaspec在过去的二十年中,荧光检测生理学和神经学信号受到了极大的关注。使用分子荧光或发光来感测生理和神经信号具有若干优点。其中包括高灵敏度(低至单个分子),开-关切换性,活细胞通信的可行性,具有亚微米可视化的亚纳米空间分辨率和亚毫秒级时间分辨率。光诱导电子转移(PET)和电子能量转移(EET)主要用于将离散的和化学计量的识别事件转换为荧光信号。基于PET效应,开发了许多荧光生理指示剂(如下所述)。AnaSpec提供高质量和具有竞争力的价格的多种生理和神经指标(例如Fura-2,Indo-1和Rhod-2),用于各种生物学应用。AnaSpec努力提供可在任何地方使用的最高纯度的指标。通过HPLC分析,我们的UltraPure级AM荧光指示剂酯的纯度通常至少为95%,尽管纯度通常超过98%。此外,我们还为您提供许多Ca2 +指示剂的AM酯的定制包装服务,以最小的费用为您提供便利,并降低了存储期间变质的风险。