Anapec/β-淀粉样蛋白(25-35),人,小鼠/大鼠/5 mg/AS-24228

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¥3980.00
货号:AS-24228
浏览量:88
品牌:Anaspec
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商品描述
DescriptionSequence(One-Letter Code)
Product NameBeta - Amyloid (25 - 35), Human, mouse/ratGSNKGAIIGLM
Size5 mg
Catalog #AS-24228
US$$199
Purity% Peak Area By HPLC ≥ 95%

Aß (25-35) is the main factor responsible for Aß neurotoxic effects.

Detailed InformationDatasheet
Material Safety Data Sheets (MSDS)
Storage-20°C
ReferencesRef: Carvalho, K. et al. Braz. J. Med. Biol. Res. 3, 1153 (1997).
Molecular Weight1060.3
GSNKGAIIGLM
Sequence(Three-Letter Code)H - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - OH
Product CitationsHung, SY. et al. (2015). LC3 overexpression reduces Aβ neurotoxicity through increasing α7nAchR expression and autophagic activity in neurons and mice. Neuropharmacol doi:10.1016/j.neuropharm.2015.02.003.Qu, J. et al. (2011)S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide. PNAS 108, 14330 (2011). doi: 10.1073/pnas.1105172108Morte, B. et al. (2011). Monocyte-mediated regulation of genes by the amyloid and prion peptides in SH-SY5Y neuroblastoma cells. Neurochem Int doi:10.1016/j.neuint.2011.01.019.Ravindran, C. et al. (2010). CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia. Cell Immunol 260, 113.Huang, W-C. et al. (2009). Enlargement of Aβ aggregates through chemokine-dependent microglial clustering. Neurosci. Res. 63, 280.Wang, HY. et al. (2009). Dissociating β-amyloid from α7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes α7 nicotinic acetylcholine and NMDA receptor function in Alzheimer"s Disease brain. J Neurosci 29, 10961.Seyb, K. et al. (2008). Identification of small molecule inhibitors of β-amyloid cytotoxicity through a cell-based high-throughput screening platform. J Biomol Screen 13, 870.Sun, K. et al. (2008). Novel Genetic Tools Reveal Cdk5’s Major Role in Golgi Fragmentation in Alzheimer’s Disease. Mol Biol Cell 19, 3052.Tateno, M. et al. (2008). Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons. Pro Neuro-Pyschopharmacol Biol Pysch 32, 1704.Hashioka, S. et al. (2007). Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation. Free Radical Bio. Med. 42, 945.Martínez, T. and A. Pascual (2007). Gene expression profile in β-amyloid-treated SH-SY5Y neuroblastoma cells.Brain Res. Bull. 72, 225.Nelson, TJ. and DL. Alkon (2007). Protection againstβ-Amyloid-induced Apoptosis by Peptides Interacting withβ-Amyloid. J. Biol. Chem. 282, 31238.Pu, F. et al. (2005). Differential effects of buckwheat and kudingcha extract on neuronal damage in cultured hippocampal neurons and spatial memory impairment induced by scopolamine in an eight-arm radial maze. J. Health Sci. 51, 636.Egashira, N. et al. (2002). Hypoxia enhances β-amyloid-induced apoptosis in rat cultured hippocampal neurons. Japanese J. Pharmacol. 90, 321.Kawahara, M. and Y. Kuroda (2001). Intracellular Calcium Changes in Neuronal Cells Induced by Alzheimer"s ß-Amyloid Protein Are Blocked by Estradiol and Cholesterol. Cell. Mol. Neurobio. 21, 1.Yatin, S. et al. (1999). Alzheimer"s amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neurosci Lett 263, 17.Yatin, SM. et al. (1998). Temporal relations among amyloid β-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses. J. Mol. Neurosci. 11, 183.
Anaspec在过去的二十年中,荧光检测生理学和神经学信号受到了极大的关注。使用分子荧光或发光来感测生理和神经信号具有若干优点。其中包括高灵敏度(低至单个分子),开-关切换性,活细胞通信的可行性,具有亚微米可视化的亚纳米空间分辨率和亚毫秒级时间分辨率。光诱导电子转移(PET)和电子能量转移(EET)主要用于将离散的和化学计量的识别事件转换为荧光信号。基于PET效应,开发了许多荧光生理指示剂(如下所述)。AnaSpec提供高质量和具有竞争力的价格的多种生理和神经指标(例如Fura-2,Indo-1和Rhod-2),用于各种生物学应用。AnaSpec努力提供可在任何地方使用的最高纯度的指标。通过HPLC分析,我们的UltraPure级AM荧光指示剂酯的纯度通常至少为95%,尽管纯度通常超过98%。此外,我们还为您提供许多Ca2 +指示剂的AM酯的定制包装服务,以最小的费用为您提供便利,并降低了存储期间变质的风险。