Additional Information:Buffer Formulation: 0.1M Tris-HCl (pH 6.8) buffer containing 0.2M DTT, 4% SDS, 0.2% Bromophenol blue and 20% Sucrose.Reconstitution and Storage:Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.Gene Symbol:RAF1Alias Symbols:NS5, CRAF, Raf-1, c-RafNCBI Gene Id:5894Protein Name:RAF proto-oncogene serine/threonine-protein kinaseDescription of Target:This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. Swissprot Id:P04049Protein Accession #:NP_002871Nucleotide Accession #:NM_002880Molecular Weight:39 Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express RAF1. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express RAF1. 
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