Gene Symbol:ACVR1Alias Symbols:FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2NCBI Gene Id:90Protein Name:Activin receptor type-1Swissprot Id:Q04771Protein Accession #:NP_001096Nucleotide Accession #:NM_001105Description of Target:Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. Molecular Weight:50 Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express ACVR1. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express ACVR1. 
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