Lysobisphosphatidicacids(LBPAs),knownalsoasbis-(monoacylglycerol)phosphates(BMPs)arespecializedlipidsreportedtoplayaroleinintracellularproteinandlipidtransportinhealthycells.Theiraccumulationwasobservedinpathologiclivertissue,andtheyalsoserveasantigensforauto-antibodygenerationinahumanautoimmuneconditiontermedantiphospholipidsyndrome.AccumulationofLBPAsinintracellular,oftenmultilamellarmembranesisrelatedtobiomembranepolymorphismwhichmayimpactintracellularcholesteroltransport.

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(S,S)Bisoleoyl-lysobisphosphatidicacidisthenaturallyoccurring,BIOLOGicallyactivieisomerofLPBA.

Solubility

MeOH:CHCl₃(1:1v/v)>1mg/mL

Storage

-20°C

FeaturedinPublications

1)Abe,A,Shayman,J.A.(2009)“TheroleofnegativelychargedlipidsinlysosomalphospholipaseA2function.”JournalofLipidResearch.50(10):2027-35.2)Chevallier,J.etal.(2008)“LysobisphosphatidicAcidControlsEndosomalCholesterolLevels”JournalofBiologicalChemistry.283:27871-278803)Yang,S-T.etal(2010)“Cell-PenetratingPeptideInducesLeakyFusionofliposomesContainingLateEndosome-SpecificAnionicLipid”BiophysicalJournal.8(20):2525–25334)Alvira,D.etal.(2011)“InhibitionofProtein-tyrosinePhosphatase1B(PTP1B)MediatesUbiquitinationandDegradationofBcr-AblProtein”JournalofBiologicalChemistry.286:32313-32323.5)Bissig,C.etal.(2013)“ViralInfectionControlledbyaCalcium-DependentLipid-BindingModuleinALIX”Cell.25(4):364-373.6)Baptist,M.,etal.(2015).“2,2-Bis(monoacylglycero)PO4(BMP),butNot3,1-BMP,IncreasesMembraneCurvatureStresstoEnhanceα-TocopherolTransferProteinBindingtoMembranes.”LipidsJanuary:1-6.

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Documents

TechnicalDataSheet

Categories	Lipids
Filter	LBPA,Lysophospholipid
CASNumber	288089-44-1
MolecularFormula	C58H114NO10P
MolecularWeight(g/mol)	1016.5
Purity	>95%
Storage	-20°Corbelow

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