TestedSpeciesReactivity:HumanPredictedSpeciesReactivity:HumanProductFormat:Liquid.Purifiedantibodysuppliedin1xPBSbufferwith0.09%(w/v)sodiumazideand2%sucrose.Clonality:PolyclonalHost:RabbitApplication:WBReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.GeneSymbol:CHEK2OfficialGeneFullName:checkpointkinase2NCBIGeneId:11200ProteinName:Serine/threonine-proteinkinaseChk2SwissprotId:O96017-4ProteinAccession#:NP_001005735.1NucleotideAccession#:NM_001005735.1AliasSymbols:CDS1,CHK2,LFS2,RAD53,hCds1,HuCds1,PP1425DescriptionofTarget:InresponsetoDNAdamageandreplicationblocks,cellcycleprogressionishaltedthroughthecontrolofcriticalcellcycleregulators.Theproteinencodedbythisgeneisacellcyclecheckpointregulatorandputativetumorsuppressor.Itcontainsaforkhead-associatedproteininteractiondomainessentialforactivationinresponsetoDNAdamageandisrapidlyphosphorylatedinresponsetoreplicationblocksandDNAdamage.Whenactivated,theencodedproteinisknowntoinhibitCDC25Cphosphatase,preventingentryintomitosis,andhasbeenshowntostABIlizethetumorsuppressorproteinp53,leADIngtocellcyclearrestinG1.Inaddition,thisproteininteractswithandphosphorylatesBRCA1,allowingBRCA1torestoresurvivalafterDNAdamage.MutationsinthisgenehavebeenlinkedwithLi-Fraumenisyndrome,ahighlypenetrantfamilialcancerphenotypeusuallyassociatedwithinheritedmutationsinTP53.Also,mutationsinthisgenearethoughttoconferapredispositiontosarcomas,breastcancer,andbraintumors.ThisnuclearproteinisamemberoftheCDS1subfamilyofserine/threonineproteinkinases.Severaltranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene. ProteinSize(#AA):452MolecularWeight:50kDaPurification:AffinitypurifiedTissueTool:FindtissuesandcelllinessupportedbyDNAarrayanalysistoexpressCHEK2.
RNASeq:FindtissuesandcelllinessupportedbyRNA-seqanalysistoexpressCHEK2.
Immunogen:TheimmunogenisasyntheticpeptidedirectedtowardstheCterminalregionofhumanCHEK2PeptideSequence:Syntheticpeptidelocatedwithinthefollowingregion:MKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAConcentration:Batchdependentwithinrange:100ulat0.5-1mg/mlBlockingPeptide:Foranti-CHEK2(ARP86993_P050)antibodyisCatalog#AAP86993Datasheets/Manuals:Printabledatasheetforanti-CHEK2(ARP86993_P050)antibody Aviva为每个蛋白质表达项目提供定制的解决方案。我们专业的科研人员对困难的蛋白质具有丰富的经验，并已生产出2500多种重组蛋白质。无论您的需求是小型研究还是大型cGMP，我们都可以运用我们的经验来满足您的需求。服务包括大肠杆菌表达，哺乳动物表达，酵母表达和抗原制备。
