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Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.

Nucleotide Accession #:

BC015033

Tissue Tool:

Find tissues and cell lines supported by DNA array analysis to express PLD2.

RNA Seq:

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Protein Interactions:

UBC; RPS6KB1; CUL3; AQP3; RPTOR; PEA15; PIP5K1A; STXBP1; DPYSL2; BIN1; MTOR; CAV1; AMPH; OPRM1; ALDOC; GM2A; PRKCD; PRKCA; PLCG1; LCK; GAPDH; FYN; EGFR; CSK; ALDOA; ARF1; ACTB; ACTN1; CAV2; SRC;

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