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This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

Swissprot Id:

P04798

Protein Accession #:

NP_000490

Nucleotide Accession #:

BC023019

Tissue Tool:

Find tissues and cell lines supported by DNA array analysis to express CYP1A1.

RNA Seq:

Find tissues and cell lines supported by RNA-seq analysis to express CYP1A1.

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