Tested Species Reactivity:HumanProduct Format:LyophilizedApplication:CAAdditional Information:Description: ANGPTL3 (Angiopoietin-Like Protein 3) is a secreted glycoprotein structurally related to the angiopoietin family of growth factors, but does not bind the angiopoietin-specific receptors Tie-2 or Tie-1. ANGPTL3 is expressed primarily in the liver during early liver development and throughout adulthood. It is found in full-length, C-terminal (fibrinogen-like) and N-terminal (coiled) formats in plasma. It is a lipoprotein lipase (LPL) inhibitor, promoting an increase in circulating triglyceride levels. ANGPTL3 also plays a role in angiogenesis, with the fibrinogen-like domain binding to integrin alpha V, beta 3 and inducing adhesion and migration of endothelial cells.:::Bioactivity: The ability to bind recombinant integrin alpha V, beta 3 is measured through a functional ELISA.:::Endotoxin Level: Endotoxin level is <0.1 ng/ug="" of="" protein=""><1>Reconstitution and Storage:-20CPurity:98%Protein Sequence:SRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL QVKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQPETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KEIENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPAEC TTSource:CHO cellsTarget Reference:Santulli G. 2014. Front Endocrinol (Lausanne). 5: 4 DOI: 10.3389/fendo.2014.00004.
Hato T, Tabat M and Oike Y. 2008. Trends Cardiovasc Med. 18(1): 6-14.
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Li C. 2006. Curr Opin Lipidol. 17(2): 152-156.
Conklin D, Gilbertson D, Taft DW, Maurer MF, Whitmore TE, Smith DL, Walker KM, Chen LH, Wattler S, Nehls M, et. al. 1999. Genomics. 62(3): 477-482.
Datasheets/Manuals:Printable datasheet for OPTA00947Gene Symbol:ANGPTL3Official Gene Full Name:angiopoietin like 3Alias Symbols:ANL3, ANG-5, FHBL2, ANGPT5NCBI Gene Id:27329Protein Name:angiopoietin-related protein 3Description of Target:This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.Molecular Weight:62 kDaTissue Tool:Find tissues and cell lines supported by DNA array analysis to express ANGPTL3. RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express ANGPTL3. Aviva为每个蛋白质表达项目提供定制的解决方案。我们专业的科研人员对困难的蛋白质具有丰富的经验，并已生产出2500多种重组蛋白质。无论您的需求是小型研究还是大型cGMP，我们都可以运用我们的经验来满足您的需求。服务包括大肠杆菌表达，哺乳动物表达，酵母表达和抗原制备。
