Predicted Species Reactivity:Human, Mouse, RatClonality:MonoclonalClone:S66-38Isotype:IgG2aHost:MouseApplication:WB, IHC, IPAdditional Information:Background Info: Detects ~34kDa. No cross reactivity against KCIPs 1,2 or 4:::Scientific Background: There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF hand containingproteins required for the traffic of channel formingKv4 K+ subunits to the plasma membrane (3).KChiP3 is also known as calsenilin and as the transcriptionfactor, downstream regulatory element antagonistmodulator (DREAM), which regulates a number of genesincluding prodynorphon. They are highly expressed in thehippocampus. Through its various functions, it may play arole in the regulation of synaptic plasticity, learning andmemory (4).:::Certificate of Analysis: 1 ug/mL was sufficient for detection of KChIP3 in 20ug of mouse brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.Reconstitution and Storage:Store at -20C. Shipping in Blue Ice or 4C.Replacement Item:This antibody may replace item sc-111016 from Santa Cruz Biotechnology.Immunogen:Fusion protein amino acids 1-256 (Full length) of rat Calsenillin/DREAM/KChIP3 Purification:Protein G PurifiedConcentration:1mg/mLDatasheets/Manuals:Printable datasheet for OASE00219Dilution:1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF)Storage Buffer:PBS pH7.4, 50% glycerolTarget Reference:1. Hille B. (2001) Ion Channels of ExcitableMembranes, 3rd Ed., Sinauer Associated Inc.:Sunderland, MA USA.2. www.iochannels.org3. Flowerdew S.E., and Burgoyne R.D. (2009) BiochemJ. 418(3): 529-540.4. Alexander J.C., et al. (2009) Learn Mem. 16(3): 167-177.Gene Symbol:Kcnip3Official Gene Full Name:Kv channel interacting protein 3, calsenilinNCBI Gene Id:65199Swissprot Id:Q9JM47Protein Accession #:NP_115851.1Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express Kcnip3. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express Kcnip3. 
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